Excitation-Contraction Coupling and Cardiac Contractile Force

Excitation-Contraction Coupling and Cardiac Contractile Force
Author :
Publisher : Springer Science & Business Media
Total Pages : 468
Release :
ISBN-10 : 9789401006583
ISBN-13 : 940100658X
Rating : 4/5 (58X Downloads)

Book Synopsis Excitation-Contraction Coupling and Cardiac Contractile Force by : Donald Bers

Download or read book Excitation-Contraction Coupling and Cardiac Contractile Force written by Donald Bers and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: How is the heartbeat generated? What controls the strength of contraction of heart muscle? What are the links between cardiac structure and function? How does our understanding of skeletal and smooth muscle and non-muscle cells influence our thinking about force development in the heart? Are there important species differences in how contraction is regulated in the heart? How do the new molecular data fit together in understanding the heart beat? What goes wrong in ischemia, hypertrophy, and heart failure? This book paints a modern `portrait' of how the heart works and in this picture the author shows a close-up of the structural, biochemical, and physiological links between excitation and contraction. The author takes the reader through a series of important, interrelated topics with great clarity and continuity and also includes many useful illustrations and tables. The book starts by considering the cellular structures involved in excitation-contraction coupling and then described the characteristics of the myofilaments as the end effector of excitation-contraction coupling. A general scheme of calcium regulation is described and the possible sources and sinks of calcium are discussed in simple, but quantitative terms. The cardiac action potential and its many underlying currents are reviewed. Then the characteristics of some key calcium transport systems (calcium channels, sodium/calcium exchange and SR calcium uptake and release) are discussed in detail. This is then built into a more integrated picture of calcium regulation in succeeding chapters by detailed discussions of excitation-calcium coupling mechanisms (in skeletal, cardiac, and smooth muscle), the interplay between calcium regulatory processes, and finally mechanisms of cardiac inotropy, calcium overload, and dysfunction (e.g., ischemia, hypertrophy, and heart failure). Excitation-Contraction Coupling and Cardiac Contractile Force – Second Edition is an invaluable source of information for anyone who is interested in how the heart beat is controlled and especially suited for students of the cardiovascular system at all levels from medical/graduate students through senior investigators in related fields.


Excitation-Contraction Coupling and Cardiac Contractile Force Related Books

Excitation-Contraction Coupling and Cardiac Contractile Force
Language: en
Pages: 468
Authors: Donald Bers
Categories: Medical
Type: BOOK - Published: 2012-12-06 - Publisher: Springer Science & Business Media

GET EBOOK

How is the heartbeat generated? What controls the strength of contraction of heart muscle? What are the links between cardiac structure and function? How does o
Excitation-Contraction Coupling and Cardiac Contractile Force
Language: en
Pages: 468
Authors: D. M. Bers
Categories: Medical
Type: BOOK - Published: 2001-08-31 - Publisher: Springer Science & Business Media

GET EBOOK

Then the characteristics of some key calcium transport systems (calcium channels, sodium/calcium exchange and SR calcium uptake and release) are discussed in de
Excitation-Contraction Coupling in Skeletal, Cardiac, and Smooth Muscle
Language: en
Pages: 450
Authors: George B. Frank
Categories: Science
Type: BOOK - Published: 2012-12-06 - Publisher: Springer Science & Business Media

GET EBOOK

The Third International Symposium on Excitation-Contraction Coupling in Skeletal, Cardiac, and Smooth Muscle, organized by George Frank, C. Paul Bianchi, and He
Core Topics in Cardiac Anesthesia
Language: en
Pages: 0
Authors: Jonathan H. Mackay
Categories: Medical
Type: BOOK - Published: 2012-03-15 - Publisher: Cambridge University Press

GET EBOOK

Since the publication of the first edition of Core Topics in Cardiac Anaesthesia, the clinical landscape has undergone significant change. Recent developments i
Calcium Signalling and Disease
Language: en
Pages: 591
Authors: Ernesto Carafoli
Categories: Medical
Type: BOOK - Published: 2007-09-29 - Publisher: Springer Science & Business Media

GET EBOOK

Authors highlight several promising discoveries in the field of calcium signaling that provide new information about both genetic and acquired pathologies. Thei